Description and review of Diltiazem
Firstly, Diltiazem is a nondihydropyridines (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. In addition, It relaxes the smooth muscles in the walls of arteries, which opens (dilates) the arteries, allows blood to flow more easily, and lowers blood pressure. Additionally, it lowers blood pressure by acting on the heart itself to reduce the rate, strength, and conduction speed of each beat. Also specializes in controling the quality and reducing the impurities of this product.
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Chemical description of Diltiazem
Product Name: Diltiazem HCl
CAS RN.: 33286-22-5
Molecular Weight: 450.9788
Molecular Formula: C22H27ClN2O4S
Melting Point(℃): 210-215℃
Boiling Point(℃): 594.4°C at 760 mmHg
Flash Point(℃): 313.3°C
Water Solubility: soluble
Hazard Symbols: Xn
Risk Codes: R22;R40
Safety Description: S36/37;S45;
Side effects of diltiazem
similarly, a reflex sympathetic response, caused by the peripheral dilation of vessels and the resulting drop in blood pressure, works to counteract the negative inotropic, chronotropic and dromotropic effects of diltiazem. Undesirable effects include hypotension, bradycardia, dizziness, and flushing.
In addition, Diltiazem is one of the most common drugs that cause drug-induced lupus, along with hydralazine, procainamide, isoniazid, minocycline.
Again, because of its inhibition of hepatic cytochromes CYP3A4, CYP2C9 and CYP2D6, there are a number of drug interactions. Some of the more important interactions are listed below.